- Saddlebrooke
- Saginaw
- Saint Clair
- Saint Clement
- Saint Cloud
- Saint Elizabeth
- Saint Francisville
- Saint George
- Saint John
- Saint Johns
- Saint Martins
- Saint Mary
- Saint Paul
- Saint Robert
- Saint Thomas
- Sainte Genevieve
- Salisbury
- Sappington
- Sarcoxie
- Schell City
- Scotsdale
- Scott City
- Sedalia
- Sedgewickville
- Seligman
- Senath
- Seneca
- Seymour
- Shelbina
- Shelbyville
- Sheldon
- Shell Knob
- Sheridan
- Shoal Creek Drive
- Shoal Creek Estates
- Sibley
- Sikeston
- Silex
- Silver Creek
- Skidmore
- Slater
- Smithton
- Smithville
- Snow Creek
- South Fork
- South Greenfield
- South Lineville
- South Van Buren
- South West City
- Spanish Lake
- Sparta
- Spickard
- Spokane
- Stanberry
- Stark City
- Steele
- Steelville
- Stella
- Stewartsville
- Stotesbury
- Stotts City
- Stoutland
- Stoutsville
- Stover
- Strafford
- Strasburg
- Sturgeon
- Sugar Creek
- Sullivan
- Summersville
- Sumner
- Sundown
- Sunrise Beach
- Sunset Hills
- Sweet Springs
- Sycamore Hills
- Syracuse